A regenerative treatment that works at a cellular level — helping the skin repair and rebuild its own quality, particularly in the delicate under-eye area. Here is the biology, the evidence, and an honest account of what to expect.
Polynucleotides are a regenerative treatment. Rather than hydrating or filling, they work at a cellular level — helping the skin repair, renew and rebuild its own quality.
Polynucleotides are purified fragments of DNA, most often derived from salmon or trout and refined to a high degree of purity. Placed into the skin, they act as biological signals: they encourage the skin's own fibroblasts — the cells that make collagen and elastin — to become more active, support the formation of new blood vessels to improve microcirculation, and calm inflammation. The effect is a gradual improvement in the skin's underlying quality and resilience.
Polynucleotides stimulate the skin's fibroblasts, the cells responsible for producing collagen and elastin, supporting renewal from within.
They encourage microcirculation and have an anti-inflammatory, antioxidant action — improving the environment in which skin renews.
Over a course, the skin becomes better hydrated, firmer and more resilient — a regenerative improvement rather than an added layer.
The biology of polynucleotides is well characterised and genuinely promising, and early clinical studies are encouraging. But the evidence is still developing: most studies are small and of low-to-moderate quality, and the specific skin mechanism is inferred from the wider tissue-repair science. We describe polynucleotides as an emerging, regenerative treatment — not a proven cure — and Matt will give you a realistic picture at consultation.
Polynucleotides are particularly suited to delicate, thin or tired skin — and above all to the under-eye area.
Thin, crepey, tired-looking under-eye skin
The delicate skin beneath the eyes is where polynucleotides are best known. By improving skin thickness, quality and microcirculation, they help refresh crepey, thin and tired under-eye skin — and can soften the shadowing that comes from poor skin quality.
Skin that has lost quality and resilience
Across the face, polynucleotides help skin that has become thin, tired or lacklustre — supporting a firmer, better-hydrated, more resilient quality through genuine renewal.
Firmness, hydration and resilience
The aim throughout is regenerated skin quality — skin that is better hydrated, firmer and more resilient because it has been helped to renew itself.
Polynucleotides are regenerative — which sets them apart from both hydration and volume.
A skin booster works chiefly by hydration — hyaluronic acid binding water in the dermis. Polynucleotides work by regeneration — signalling the skin's own cells to repair and renew. Both improve skin quality without volume, and they are sometimes combined; Matt will advise which suits your skin, or whether both do.
A filler adds volume and structure. Polynucleotides add neither — they improve the quality and resilience of the skin itself. Under the eyes in particular, the distinction matters: where the issue is thin, poor-quality skin, polynucleotides are often the better route; where it's true volume loss, a filler conversation with our nurse prescriber is more appropriate.
Polynucleotides have a favourable safety profile in the published studies. A few honest points guide the conversation at consultation.
This one matters.
What to expect as the skin settles.
For your safety, treatment isn't possible in these situations.
This is a guide to help you prepare — it isn't a diagnosis, and it isn't exhaustive. Your full history is always reviewed at consultation.
Every polynucleotide plan begins with Matt assessing your skin, so treatment is matched to what your skin actually needs — never picked from a list.