Polynucleotide solution placed across the skin during treatment at MNP Clinic Hornchurch
Polynucleotides crest EST. 2016 Matt Newbery · Injectables · Hornchurch

Polynucleotides.

Expertise first. Treatment second. Less adding. More restoring.

A regenerative treatment that helps the skin repair and renew its own quality — delivered two ways at Hornchurch: infused through SkinPen microchannels, or injected with the Plinest® range by Mastelli.

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Preparing the polynucleotide solution in clinic at Hornchurch
i. The Approach

Not hydration.
Regeneration.

Polynucleotides are purified fragments of DNA that act as biological signals in the skin — encouraging its own cells to repair, renew and rebuild quality from within. This is a regenerative treatment, not a filler and not simply a hydrator. Skin helped to renew itself.

Best known for the delicate under-eye area, polynucleotides are a favourite of Matt’s for tired, thin or lacklustre skin. Practitioner-led throughout.

Two Ways In

One molecule.
Two deliveries.

Polynucleotides can reach the skin two ways — and the right route is a consultation decision, not a menu choice.

Route One · Infused

Through SkinPen microchannels.

The polynucleotide solution is delivered into the skin through the microchannels SkinPen creates — regeneration folded into the microneedling itself, with no injections. This is the treatment in the film below.

Route Two · Injected

The Plinest® injectable range.

Placed precisely where the skin needs it by fine intradermal injection — three formulations for three jobs, from the delicate eye area to deeper facial remodelling. The range is below.

The Film

The treatment, explained.

A closer look at the SkinPen-delivered infusion at Hornchurch — the regenerative thinking behind it.

Route One in clinic — the polynucleotide infusion, SkinPen-delivered.

Route Two · The Injectables

Three formulations.
One family.

For the injectable route we use the Plinest® range by Mastelli — the original Italian polynucleotide house, made with their patented PN-HPT® purification. Which formulation, and how many sessions, is decided at your consultation.

Plinest® Face

The Face · 2ml

Advanced facial skin regeneration — the highest concentration of purified polynucleotides, designed to improve skin quality, texture, firmness and elasticity. A full 2ml treatment; a short course, one session every two to three weeks.

Plinest® Eye

The Eye Area · 2ml

Targeted regeneration for the delicate eye area — a gentler concentration, placed with restraint. For fine lines, crepiness, elasticity and overall skin quality around the eyes. A full 2ml treatment; a short course, two to three weeks apart.

Newest®

PN-HPT® + HA + Mannitol · 2ml

PN-HPT® polynucleotides combined with hyaluronic acid and mannitol — regeneration with an additional focus on hydration, plumpness and luminosity. A full 2ml treatment; suited to mature or dehydrated skin, and as the maintenance choice once a course is complete.

No two skins need the same formulation — your course is recommended at consultation, honestly. And where deeper resurfacing is the goal, Plinest® is also the preparation we recommend ahead of NeoGen EVO — conditioning the skin before plasma regeneration.

ii. How It Works

Repair, from within
the skin.

However they arrive — infused through microchannels or placed by needle — the biology is the same. In the skin, polynucleotides encourage the fibroblasts — the cells that make collagen and elastin — to become more active, support microcirculation, and calm inflammation. The effect is a gradual improvement in the skin’s underlying quality and resilience.

Under the eyes in particular, they help refresh thin, crepey and tired-looking skin — improving quality rather than adding volume.

Explore the Science →
In Treatment

In clinic. In person.

Every injectable at MNP is placed personally — the same hands, the same standard, whatever the treatment.

Matt in treatment at the Hornchurch clinic.

iii. Who It Suits

Made for skin
that needs renewing.

✦

The under-eye area

Thin, crepey or tired under-eye skin — polynucleotides improve quality and can soften skin-quality shadowing.

✦

Tired, thinning skin

Skin that’s lost quality and resilience — supported to renew itself for a firmer, healthier look.

✦

Overall skin quality

A regenerative improvement in hydration, firmness and resilience across the face.

An honest note: under-eye dark circles have several causes. Polynucleotides help where the issue is thin or poor-quality skin — less so where it’s true hollowing or pigmentation. Matt will assess which applies to you, and tell you honestly what to expect.

Pricing

The
investment.

Plinest® Eye2ml · course of 3 — £600
£225
Plinest® Face2ml · course of 3 — £675
£250
Newest®2ml · PN-HPT® + hyaluronic acid · course of 3 — £750
£275

The SkinPen-delivered infusion is priced at consultation. Polynucleotides are usually a short course for best results — every plan begins with an honest recommendation.

Good to Know

Questions, answered.

What are polynucleotides made from?
Purified fragments of DNA, most often derived from salmon or trout and highly refined. If you have a fish or seafood allergy, please tell us — as a precaution, treatment may not be suitable.
Are they the same as Profhilo?
No. Both improve skin quality without volume, but Profhilo works chiefly by hydration, while polynucleotides are regenerative — helping the skin’s own cells repair and renew. They’re sometimes combined.
Is there downtime?
Minimal. Small raised points and possible minor bruising, especially under the eyes, usually settle within a day or so.
How many sessions will I need?
Typically a short course of sessions a few weeks apart, with maintenance thereafter. Matt will map out the right plan for your skin.
Will they help my dark circles?
It depends on the cause. Where it’s thin, poor-quality skin, polynucleotides often help. Where it’s true hollowing or pigmentation, another approach may suit better — Matt will assess and advise.
Polynucleotides crest

Book a consultation.

Every treatment begins with a conversation — never a rushed decision.

Book Your Consultation
A note from Matt

“Polynucleotides are one of the most exciting things I offer — genuinely regenerative, and beautiful for tired under-eye skin. As always, I’ll tell you honestly whether they’re right for your skin before we begin.”

Matt NewberySkin & Brow Specialist
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